Right. My own PhD work was on designing custom transcription factors to bind to specific sequences (not even with TALENs- it tried to do full molecular dynamics to predict the binding constant for multiple different DNA sequences, which was absurdly expensive). It would have to be re-engineered once for each sequence; with CRISPR, you just provide a matching template sequence.
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Right. My own PhD work was on designing custom transcription factors to bind to specific sequences (not even with TALENs- it tried to do full molecular dynamics to predict the binding constant for multiple different DNA sequences, which was absurdly expensive). It would have to be re-engineered once for each sequence; with CRISPR, you just provide a matching template sequence.