some way of us hinting to the plugin which domains were needed to not break the site:

I had collated this so far to mostly un-break the site -- for viewing at least:

    www.theguardian.com guardianapps.co.uk * noop
    www.theguardian.com guim.co.uk * noop
    www.theguardian.com theguardian.tv * noop

Whenever I un-break myself a site, I add the proper rules in there: https://github.com/gorhill/uBlock/wiki/Dynamic-filtering:-de...

There were 16 3rd-party root domains I found were not needed [1]. Probably fonts.googleapis.com would make the site looks better, but it's up to users whether they want to let Google know they have been visiting what article on the Guardian.

[1] adnxs.com criteo.com doubleclick.net fonts.googleapis.com google.com googleadservices.com googlesyndication.com googletagservices.com gstatic.com imrworldwide.com krxd.net mathtag.com moatads.com ophan.co.uk outbrain.com revsci.net scorecardresearch.com