The things that really count break very infrequently or at all (e.g. the wings are not going to fall off); in that respect I'm only worried about engine failure at takeoff, and modern turbine engines are very reliable. I'm a lot more worried about pilot error.

If you drive in the US, and you're careful about it, the risks are probably around the same magnitude (in raw risks for all drivers and passengers, especially when done by distance, commercial flight is very much safer).