Currently have a .me for my personal email but am switching to a .com soon.

For which TLD to choose, it really depends on the use case. For just personal email, or if your site is catered to more tech people you can really use anything. If it is being used more for the public I'd be careful because many people don't know things past .com or .net

I often get .co for sites and it usually works fine, but sometimes I've seen non tech savvy people mistake it as a typo and send emails to the .com version