Seems to me that if you're solving a real problem for a real audience and put in the doing the market schlep, then it would be easy enough for you to reach your customers in the 5,000,000.
No one publishes a list of the Fortune 5,000,000. But having a convenient list of 500 companies published in a magazine once a year doesn't make them any more likely to pay attention to you anyway.
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The problem this post neglects is distribution. Hunting and finding potential customers among 5,000,000 is a lot more difficult than among 500.
Seems to me that if you're solving a real problem for a real audience and put in the doing the market schlep, then it would be easy enough for you to reach your customers in the 5,000,000.
No one publishes a list of the Fortune 5,000,000. But having a convenient list of 500 companies published in a magazine once a year doesn't make them any more likely to pay attention to you anyway.