You say it's been a year or two since you tried Xamarin Studio + F# -- I urge you to give it a try again, using up-to-date versions of both (and Mono too). There has been a significant amount of effort put forth by the F# community in the past year to improve the F# + Mono + Xamarin Studio stack; in fact, Xamarin hired one of the best F# developers/consultants in the community (@7sharp9) specifically to improve F# support in Mono and Xamarin Studio.
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You say it's been a year or two since you tried Xamarin Studio + F# -- I urge you to give it a try again, using up-to-date versions of both (and Mono too). There has been a significant amount of effort put forth by the F# community in the past year to improve the F# + Mono + Xamarin Studio stack; in fact, Xamarin hired one of the best F# developers/consultants in the community (@7sharp9) specifically to improve F# support in Mono and Xamarin Studio.
If you have any questions, or you try F# + XS + OSX again and still run into issues, post something to the fsharp-opensource list (https://groups.google.com/forum/#!forum/fsharp-opensource), or ask on StackOverflow.