Nicotine on its own is vasoconstrictive. The compounds in tobacco smoke altogether are dialative. Tobacco smoke has MOAB agonists and aromatase inhibitors. Tobacco smoke lowers serotonin sensitivity while I don't think pure nicotine does this.
Vaping is really not a substitute for tobacco smoke as it is missing a bunch of chemicals.
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Nicotine on its own is vasoconstrictive. The compounds in tobacco smoke altogether are dialative. Tobacco smoke has MOAB agonists and aromatase inhibitors. Tobacco smoke lowers serotonin sensitivity while I don't think pure nicotine does this.
Vaping is really not a substitute for tobacco smoke as it is missing a bunch of chemicals.