At this point I consider Calico to be a part of Google (although separately incorporated). Not sure about you but I definitely see "extending the average life expectancy of the human population" as a difficult problem.

But even discounting this (naysayers will cry foul at the fact that it technically is a separate company), I think organizing the world's information is certainly an extremely difficult problem. And certainly one that Google is attempting to solve in more ways than search.

Also - self driving cars? Certainly you will agree that is not trivial.