I think that this chart (sourced from Figure 4) is rather telling. I changed the order to reflect the cumulative weight of each of the factors, then added in whether the study considers each item to be a harm to others, or a harm to the user.

Economic cost (CW 12·8) - others

Injury (CW 11·5) - others

Crime (CW 10·2) - others

Family adversities (CW 8·9) - others

Drug-related mortality (CW 6·4) - users

Dependence (CW 5·7) - users

Drug-specific impairment of mental functioning (CW 5·7) - users

Drug-related impairment of mental functioning (CW 5·7) - users

Drug-specific mortality (CW 5·1) - users

Loss of tangibles (CW 4·5) - users

Loss of relationships (CW 4·5) - users

Drug-specific damage (CW 4·1) - users

Drug-related damage (CW 4·1) - users

Environmental damage (CW 3·8) - others

International damage (CW 3·8) - others

Community (CW 3·2) - others