It's going to be replicated because we already know the mechanism of action. That said, many/most people would probably be better off solving the problem more upstream via whatever B-complex vitamins they need based on their bloodwork and DNA methylation variants.
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Creatine supplementation is showing some promising indications of being a low cost, mild to moderate intervention https://www.psychologytoday.com/us/blog/the-modern-brain/202...
I definitely wouldn't be sharing that as evidence of anything much at all
Google scholar link for the article https://scholar.google.com/scholar?cluster=10296105574478709...
Whether this ends up being replicated or not, I love the classic gym bro supplement being studied for its potential benefits to the brain.
What a time to be alive
It's going to be replicated because we already know the mechanism of action. That said, many/most people would probably be better off solving the problem more upstream via whatever B-complex vitamins they need based on their bloodwork and DNA methylation variants.