As to

clinically relevant impact is, so far, disappointingly limited

it could be that the AI tools have to get to some threshold before they are very useful? Like with the Economist talking to Hassabis:

AlphaFold itself took six years of work to predict its first protein structure, and then one year to follow up with what he describes as the structures of “all 200m proteins known to science”. He hopes a similar speedup will happen inside Isomorphic.