Comment on Can Ozempic Cure Addiction?Comments−glp1guide7moNo one knows of course, but it's looking likely -- anecdotal data is piling up.That said, there are some that have reported it also lessens desire for things they want to desire.Did a writeup on this back in summer '25:https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-...Paywalled so direct links to notable papers through the years below:https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218https://pubmed.ncbi.nlm.nih.gov/36031011https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505https://pubmed.ncbi.nlm.nih.gov/39764175https://pubmed.ncbi.nlm.nih.gov/39032839/https://www.science.org/content/article/obesity-drug-cuts-op... https://www.statnews.com/2024/02/17/opioid-cravings-glp1-wei... (The science.org article is paywalled IIRC)https://pubmed.ncbi.nlm.nih.gov/39535805/https://pubmed.ncbi.nlm.nih.gov/39937469/Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.Eli Lilly has taken to calling GLP1s "anti-hedonics" as well−pixl977moThis brings up another interesting question. What is the chemical basis of desire in the brain?−torusle7moEasy, it is dopamine.−greygoo2227moNo it isn't. Every neurotransmitter is involved with every complex phenomenon.
Comments
No one knows of course, but it's looking likely -- anecdotal data is piling up.
That said, there are some that have reported it also lessens desire for things they want to desire.
Did a writeup on this back in summer '25:
https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-...
Paywalled so direct links to notable papers through the years below:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504
https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218
https://pubmed.ncbi.nlm.nih.gov/36031011
https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505
https://pubmed.ncbi.nlm.nih.gov/39764175
https://pubmed.ncbi.nlm.nih.gov/39032839/
https://www.science.org/content/article/obesity-drug-cuts-op... https://www.statnews.com/2024/02/17/opioid-cravings-glp1-wei... (The science.org article is paywalled IIRC)
https://pubmed.ncbi.nlm.nih.gov/39535805/
https://pubmed.ncbi.nlm.nih.gov/39937469/
Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.
Eli Lilly has taken to calling GLP1s "anti-hedonics" as well
This brings up another interesting question. What is the chemical basis of desire in the brain?
Easy, it is dopamine.
No it isn't. Every neurotransmitter is involved with every complex phenomenon.