Have you looked at Pyramid? It's pretty awesome, really the ideal framework philosophy in my opinion (i.e., actually a framework instead of attempting to be a crappy domain-specific language/replacement standard library). It's also Python 3.x compatible and has been for several months (they replaced the one library they had been holding out for).

I gave Django a couple of truly honest tries, but I just couldn't bring myself to tolerate it. Pyramid is by far the best.