Best thing to do is never sync with iTunes. Just detach completely.
I set my iPad up (and my new iPhone) without iTunes at all. iCloud backup let me move from an iPhone 4 to 5 without a USB cable at all and all my data moved over perfectly.
I plug in to my computer to transfer videos that don't transfer using Photostream. I also occasionally will do a sync of movies for a trip.
Music is iTunes Match. Photos are Photostream. Email is IMAP. Contacts/Calendars/etc is iCloud.
It actually works very well and I'm able to move to new devices or restore from a backup without issues.
Comments
I was bitten by that with my new iPad. It is not at all obvious that 'backed up' isn't actually all backed up.
Best thing to do is never sync with iTunes. Just detach completely.
I set my iPad up (and my new iPhone) without iTunes at all. iCloud backup let me move from an iPhone 4 to 5 without a USB cable at all and all my data moved over perfectly.
I plug in to my computer to transfer videos that don't transfer using Photostream. I also occasionally will do a sync of movies for a trip.
Music is iTunes Match. Photos are Photostream. Email is IMAP. Contacts/Calendars/etc is iCloud.
It actually works very well and I'm able to move to new devices or restore from a backup without issues.
No iTunes is the answer!