I transitioned from a "normal" keyboard to a Glove80 last year. I immediately didn't like using the standard layout, so I switched to Colemak-DH which I've found pretty comfortable.
The thumb clusters are definitely a pain, I find myself only really using the 3 closest buttons one each side. Even then, the closest button on the upper row requires a stretch that gets uncomfortable after a while. It hasn't been bad enough for me to consider trying other keyboards though--the prices are too high for me to feel comfortable buying something I might not like.
To anyone that switches to a split keyboard, I strongly recommend also getting a trackball mouse (I use a Ploopy Adept). It lets you center the keyboard in front of you without needing to stretch too far while manipulating the mouse.
Comments
I transitioned from a "normal" keyboard to a Glove80 last year. I immediately didn't like using the standard layout, so I switched to Colemak-DH which I've found pretty comfortable.
The thumb clusters are definitely a pain, I find myself only really using the 3 closest buttons one each side. Even then, the closest button on the upper row requires a stretch that gets uncomfortable after a while. It hasn't been bad enough for me to consider trying other keyboards though--the prices are too high for me to feel comfortable buying something I might not like.
To anyone that switches to a split keyboard, I strongly recommend also getting a trackball mouse (I use a Ploopy Adept). It lets you center the keyboard in front of you without needing to stretch too far while manipulating the mouse.