I see some parallels with magnetic resonance imaging. I worked on a project optimizing MRI scans a few years back. I remember the PI in the project essentially acknowledging that analyzing single MRI images is absolutely more art than science, but there's a ton of value in getting periodic MRIs (say yearly) and looking at the diffs. I imagine a lot of the value coming from Rubin will be due to this, as well as the reason it was built for speed.