That's not even true except in the sense that the browser will (most likely) run it (well, some subset of it...). Compilation or transpilation of a language are not considered to be "going out of your way", unless you only program in assembly. And even JS-based stacks tend to have some form of compilation step to gather and process 'assets bundles'. So why not use a modern language that has more web-oriented features than JS?
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That's not even true except in the sense that the browser will (most likely) run it (well, some subset of it...). Compilation or transpilation of a language are not considered to be "going out of your way", unless you only program in assembly. And even JS-based stacks tend to have some form of compilation step to gather and process 'assets bundles'. So why not use a modern language that has more web-oriented features than JS?