Author is right in their dismissive attitude of Pyodide, but their WASM-ward gaze is probably misplaced, too. Once you're talking about acceptability in terms of being "Python-like enough", you should really be considering a Python-like syntax for JS, which would suffice for a bunch of Python programmers (in particular those who only picked it up as a result of ill-considered advocacy by Python proponents who told them that e.g. Python is how science gets done).