Do you know how large the biggest hard disks or SSDs are nowadays? [...] no single disk will have 281 Terabytes of space. And that is what you need: Since SQLite files are single, continuous files on your file system, they have to be stored on one, physical hard drive. You could theoretically split them up, but then they wouldn’t work anymore until you pieced them together again.

So the practical limit of the size of an SQLite file is much lower than the theoretical limit.

I agree with the conclusion, but the argument is horrible. 281 TB are easily doable on a single file system (not hard drive, which is entirely irrelevant) is very much doable. You can actually build a rather cheap consumer system that will do that. It won't be good, but the problem is not the continuous allocation of space.