It's not that hard, in patients with cancer, it's very common for the immune system to go after the cancer specific mutations, until the cancer learns to express the cell-surface checkpoints that deactivate the immune system.
Its extremely rare (or at least I have not heard of it) to develop auto-immune activity during the course of cancer.
T-cell receptors that recogize HLA-bound epitopes tend to be extremely specific, and rarely go after other parts of the body. There's nothing special about cancer in this regard.
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It's not that hard, in patients with cancer, it's very common for the immune system to go after the cancer specific mutations, until the cancer learns to express the cell-surface checkpoints that deactivate the immune system.
Its extremely rare (or at least I have not heard of it) to develop auto-immune activity during the course of cancer.
T-cell receptors that recogize HLA-bound epitopes tend to be extremely specific, and rarely go after other parts of the body. There's nothing special about cancer in this regard.