It depends what you are doing. If you have a lot of semi structured data, like documents, then go with a document oriented database. If you have semi-structured data that you don't want to do much analytics on, consider a key/value store. But it you require full ACID properties, want to reduce your application code and not worry so much about integrity, then an RDBMS is still the way to go.
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It depends what you are doing. If you have a lot of semi structured data, like documents, then go with a document oriented database. If you have semi-structured data that you don't want to do much analytics on, consider a key/value store. But it you require full ACID properties, want to reduce your application code and not worry so much about integrity, then an RDBMS is still the way to go.