Responses vary by individual, and can vary by long term exposure too.

I was hospitalized for a long time because of a very serious, bad case of mumps as an adult and in the hospital I was treated they were very serious about controlling my diet so I couldn't drink coffee for a long while.

When I recovered and went back home, I started drinking the same amount of coffee I was used to, which normally wouldn't make me feel anything out of the ordinary, but because I had not been exposed to caffeine for a while, I ended up with a severe feeling of tingling in my limbs, the level of stimulation really shocked me. After a month and half (possibly a little more, I'm fuzzy on the passing of days during those times) of not drinking coffee, it was as if I had been a new coffee drinker again and my body forgot caffeine. Habitual, daily exposure can /strongly/ affect the amount of caffeine it will take for you to feel its presence at a symptomatic level, and abstaining from caffeine for a long enough period can also completely throw you back to the beginning stage.