I don't currently have any SPDY experience so if there is a "best practice" for this I'm unaware of it. With that said, I would take a two pronged approach. On the server side you could set a timeout on that user's session to reclaim resources after a period of time that you deem reasonable, regardless of whether you've received an explicit "I'm done" from the user's browser. I would hope server's implementing SPDY would also allow a way to explicitly end a connection as well. If so, I would close the connection at the time that user's session expires.
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I don't currently have any SPDY experience so if there is a "best practice" for this I'm unaware of it. With that said, I would take a two pronged approach. On the server side you could set a timeout on that user's session to reclaim resources after a period of time that you deem reasonable, regardless of whether you've received an explicit "I'm done" from the user's browser. I would hope server's implementing SPDY would also allow a way to explicitly end a connection as well. If so, I would close the connection at the time that user's session expires.