Plenty of long-covid and years before that me-cfs have of course thought of sun and vitamin D
The issue is far deeper and more complex than any offhand supplement or "biohack" anyone can casually ponder.
It's a core cell programming issue that is not easily resolved if even possible at all with the limit of current technology.
Many times it appears as an "energy issue" with many related diseases. Many long-covid patients also seem to spontaneously developed a new kind of diabetes which is definitely related to cell energy uptake (or rather lack of it). Some also develop sciatica, raynaulds and other nerve damage issues also tied to cell energy.
And I should clarify there is more than one kind of long-covid. Some people self-resolve in months, often giving credit the last thing they took or did but really it would have happened anyway.
But in contrast here is the very careful, very detailed journal of Brandon Gilles who was a very smart person, a hacker like us, who despite all that died from covid/long-covid.
Do you know the timeline of his symptoms and death? The symptoms are very similar to what flouroquinolone causes, but from my experience death is extremely rare.
I am in touch with physicians and many people and we discovered many things that people are trying that are mentioned in the blog. TNF-a inhibitors, anti-histamines and diets. Plus, many of the supplements listed.
I much appreciate all the work on that blog and will give it a good read at some point.
Those are the symptoms of a mitochondrial dysfunction. One cannot compensate it with only a diet, TNF-a inhibitors, or anti-histamines.
By quickly scrolling through the blog, "Energy Supplementation" section caught my attention. I already could see that the guy made a grave mistake there. Instead of meticulously compensating the activity of mitochondrial enzymes with the whole RDA spectrum of vitamins, including therapeutical quantities of B1, B3, and B7 coenzymes, he just sporadically included some stuff from here and there. Unfortunately, this is not enough to move the needle in terms of ATP yield. And without the sufficient levels of ATP, all other functions of the body go downhill. The speed of that decline is individual, sometimes it's mere months from onset to terminal. Most of the times, however, it's a multi-year and even multi-decade struggle.
The second grave mistake is concentrating too much on secondary symptoms (inflammation, shortness of breath, blood-clotting, autoimmune) without adequately fixing the root cause (energy depletion) that caused all of them.
The third grave mistake is presented in section "Things that hurt" -> "Supplements" -> "Thiamine is a histamine liberator and DAO inhibitor", which means that the guy didn't use it at all. And this is the gravest mistake of them all. It's true that the thiamine (B1) may increase histamine levels for some individuals, but mitochondria cannot function without it, like at all. The reason for that is thiamine-activated enzymes that sit at the very start of OXPHOS pathway. Without sufficient levels of thiamine, those enzymes cannot work. As the result, nearly all consequent parts of OXPHOS metabolic pathway become dysfunctional, rendering a low ATP yield at the output even lower. This is why one can see thiamine (B1) as an OXPHOS gatekeeper - not enough thiamine means that the input gates are mostly closed, leading to a diminished throughput of the whole chain of respiratory enzymes, unless a proper dose of thiamine is in place to "open" the gates. In a compromised mitochondrion, the right dose of thiamine is way higher than normal, reaching 100x-1000x of RDA.
(IMHO, this is what happens when a hacker incorrectly identifies a place to fix the bug and prefers to apply downstream workarounds instead of fixing the upstream root cause. In software, we almost always have a second chance, but in bioware - we may not have it at all.)
Returning to your question, the symptoms are very much like beriberi and pellagra. The cause of death is likely to be a multi-organ failure which can be manifested either as a heart attack, hypertensive crisis, liver dysfunction, renal failure, brain and nervous system damage, or a combination of those.
Comments
Plenty of long-covid and years before that me-cfs have of course thought of sun and vitamin D
The issue is far deeper and more complex than any offhand supplement or "biohack" anyone can casually ponder.
It's a core cell programming issue that is not easily resolved if even possible at all with the limit of current technology.
Many times it appears as an "energy issue" with many related diseases. Many long-covid patients also seem to spontaneously developed a new kind of diabetes which is definitely related to cell energy uptake (or rather lack of it). Some also develop sciatica, raynaulds and other nerve damage issues also tied to cell energy.
And I should clarify there is more than one kind of long-covid. Some people self-resolve in months, often giving credit the last thing they took or did but really it would have happened anyway.
But in contrast here is the very careful, very detailed journal of Brandon Gilles who was a very smart person, a hacker like us, who despite all that died from covid/long-covid.
https://docs.google.com/document/d/1X3dNPgEuQ2j8x7w8OqLEDP7l...
Do you know the timeline of his symptoms and death? The symptoms are very similar to what flouroquinolone causes, but from my experience death is extremely rare.
I am in touch with physicians and many people and we discovered many things that people are trying that are mentioned in the blog. TNF-a inhibitors, anti-histamines and diets. Plus, many of the supplements listed.
I much appreciate all the work on that blog and will give it a good read at some point.
Those are the symptoms of a mitochondrial dysfunction. One cannot compensate it with only a diet, TNF-a inhibitors, or anti-histamines.
By quickly scrolling through the blog, "Energy Supplementation" section caught my attention. I already could see that the guy made a grave mistake there. Instead of meticulously compensating the activity of mitochondrial enzymes with the whole RDA spectrum of vitamins, including therapeutical quantities of B1, B3, and B7 coenzymes, he just sporadically included some stuff from here and there. Unfortunately, this is not enough to move the needle in terms of ATP yield. And without the sufficient levels of ATP, all other functions of the body go downhill. The speed of that decline is individual, sometimes it's mere months from onset to terminal. Most of the times, however, it's a multi-year and even multi-decade struggle.
The second grave mistake is concentrating too much on secondary symptoms (inflammation, shortness of breath, blood-clotting, autoimmune) without adequately fixing the root cause (energy depletion) that caused all of them.
The third grave mistake is presented in section "Things that hurt" -> "Supplements" -> "Thiamine is a histamine liberator and DAO inhibitor", which means that the guy didn't use it at all. And this is the gravest mistake of them all. It's true that the thiamine (B1) may increase histamine levels for some individuals, but mitochondria cannot function without it, like at all. The reason for that is thiamine-activated enzymes that sit at the very start of OXPHOS pathway. Without sufficient levels of thiamine, those enzymes cannot work. As the result, nearly all consequent parts of OXPHOS metabolic pathway become dysfunctional, rendering a low ATP yield at the output even lower. This is why one can see thiamine (B1) as an OXPHOS gatekeeper - not enough thiamine means that the input gates are mostly closed, leading to a diminished throughput of the whole chain of respiratory enzymes, unless a proper dose of thiamine is in place to "open" the gates. In a compromised mitochondrion, the right dose of thiamine is way higher than normal, reaching 100x-1000x of RDA.
(IMHO, this is what happens when a hacker incorrectly identifies a place to fix the bug and prefers to apply downstream workarounds instead of fixing the upstream root cause. In software, we almost always have a second chance, but in bioware - we may not have it at all.)
Returning to your question, the symptoms are very much like beriberi and pellagra. The cause of death is likely to be a multi-organ failure which can be manifested either as a heart attack, hypertensive crisis, liver dysfunction, renal failure, brain and nervous system damage, or a combination of those.