I've worked on ultrasound systems that definitely worked this way, not just in theory but also in practice. Bandpass filter 20–40 kHz, sample directly at 40 kHz (giving 20 kHz bandwidth). No mixer step involved, but your spectrum becomes inverted (e.g. if you do an FFT, a 22 kHz tone will be in the 18 kHz bin, not the 2 kHz bin as you would perhaps expect).
Aliasing makes more sense (to me, anyway) if you think about the spectrum of complex signals, in which signals of real samples are modeled as the sum of positive and negative frequencies.
In the sampling operation, all sinusoids are shifted down to the "natural baseband" by adding or subtracting some multiple of the sampling frequency that places the resulting frequency within +/- half of the sampling frequency. So for your example of 22kHz, that real frequency has two components: +22kHz that gets shifted down to -18kHz=22kHz-40kHz, and -22kHz that gets shifted up to +18kHz=-22kHz+40kHz.
Note that this "natural baseband" is an abstraction of our own invention. You can just as easily think of the spectrum as ranging from 0Hz to the sampling frequency f_s, rather than -f_s/2 to f_s/2. The fact that some prefer one over the other is precisely why fftshift exists.
Comments
I've worked on ultrasound systems that definitely worked this way, not just in theory but also in practice. Bandpass filter 20–40 kHz, sample directly at 40 kHz (giving 20 kHz bandwidth). No mixer step involved, but your spectrum becomes inverted (e.g. if you do an FFT, a 22 kHz tone will be in the 18 kHz bin, not the 2 kHz bin as you would perhaps expect).
Aliasing makes more sense (to me, anyway) if you think about the spectrum of complex signals, in which signals of real samples are modeled as the sum of positive and negative frequencies.
In the sampling operation, all sinusoids are shifted down to the "natural baseband" by adding or subtracting some multiple of the sampling frequency that places the resulting frequency within +/- half of the sampling frequency. So for your example of 22kHz, that real frequency has two components: +22kHz that gets shifted down to -18kHz=22kHz-40kHz, and -22kHz that gets shifted up to +18kHz=-22kHz+40kHz.
Note that this "natural baseband" is an abstraction of our own invention. You can just as easily think of the spectrum as ranging from 0Hz to the sampling frequency f_s, rather than -f_s/2 to f_s/2. The fact that some prefer one over the other is precisely why fftshift exists.