I wouldn't take it that seriously, because to be completely honest, the article sounds to me like a troll post. The title and the content seems to be chosen for the biggest impact and there doesn't seem to be much more to it. The fact is that this questions have been asked and tried to answer many times by scientists, philosophers and epistemologists.

For instance, the author chose to talk about Hume but chose not to mention Popper. Falsifiability is the key word here. Science doesn't advance by gathering knowledge about how the world works directly, but by accumulating false results.

And besides, the fact that there will always be mysteries is what makes science fun in the first place.