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If Guix uses Nix under the hood, is it "just" Nix with an S-expression syntax (admittedly much better than Nix syntax) and fewer packages? If so, is there a really compelling reason to prefer Guix over NixOS? The only substantive difference I'm aware of is the use of GNU Shepherd instead of systemd.

As far as I know it doesn't use nix under the hood, it's a reimplementation of nix in guile scheme.

Ah, my mistake. I was certain it wrapped around Nix for some reason.

Same backend, but different frontend, so to speak. Hence, it used to be possible to have nix and guix share a store and local state directory. Not sure if that's still possible today, though...

It isn't.

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