I was lucky enough to see Sam Aaron rehearse his ClojureConj course at skillsmatter last week. The room was full of musicians who know Clojure. Personally, I think overtone has potential. It's already usable as an alternative synth design tool (beats the hell out of visual design). As for taking on Cubase... There are all sorts of features it doesn't have (like a usable UI), but as sam says... pull requests are welcome. :)