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Speaking as a nanoengineer now doing a web startup (in SF for 2 weeks now), this is just the way the world works.

Startups and nanoparticles can spontaneously form anywhere under the right environmental conditions, but they can just as easily break up in isolation. But if the local concentration is high enough, something magical happens. Even when a person or a molecule jumps ship, another one fills its place almost instantly. Suddenly, these things are "stable" but not only that, they can grow, sucking up bits from the surrounding environment and merging with others.

Critical mass, in SV it's the right kind of people, in nanoengineering it's the right kind of molecule, either way, once it gets going, you just hang on for the ride.

*http://en.wikipedia.org/wiki/Critical_micelle_concentration is one nanoengineering example but there are others.

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