Not OP but my experience trying out nuitka vs PyInstaller on atbswp[0] is nuitka takes significantly longer (and CPU time) to run and in my case the resulting executable wasn't working, it was because I use wxPython or some hidden import in my dependencies, I don't remember exactly. Bottom-line I think nuitka is great if you (or your dependencies) does not do black magic in the imports, otherwise you're in for a lot of debugging.
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Not OP but my experience trying out nuitka vs PyInstaller on atbswp[0] is nuitka takes significantly longer (and CPU time) to run and in my case the resulting executable wasn't working, it was because I use wxPython or some hidden import in my dependencies, I don't remember exactly. Bottom-line I think nuitka is great if you (or your dependencies) does not do black magic in the imports, otherwise you're in for a lot of debugging.
0: https://github.com/rmpr/atbswp