I would honestly manually recreate my simple PCB designs in Falstad's simulator[1] and use judgment to decide whether further thermal or high-freq analysis is necessary.

I haven't looked in a few years, but you'll likely be hard-pressed to find an open source simulator that will give you analog, pure digital, "real" digital (logic with slew/noise/nonlinearities), electromagnetic, and thermal simulations plus usability.

ANSYS is a well-established professional simulation suite and doesn't even really meet the usability threshold, in my opinion.

[1] https://www.falstad.com/circuit/