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Comment on Caffeine appears to reduce the volume of gray matter, effect being reversible

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It must be hard to do double-blind studies about caffeine, since at a typical dose it’d easy to tell the difference between caffeine and a placebo.

Especially considering these subjects all drank coffee daily, so the placebo group would experience withdrawal.

Bigger problem is probably just the sample size of 20 and sampling given that it was likely just college students

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