All the things that can go wrong with globally distributed databases. You can just run an HA cluster in a single region if you're looking to keep it simple, just the same way you can run a single-region app on Fly if you like.
We try to go out of our way to say that this stuff isn't a perfect fit for every application or a "best" way to do things. I think if a deployment like this is attractive for your application, you probably know it. I'm certainly not going to evangelize against people scaling up single-region databases!
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All the things that can go wrong with globally distributed databases. You can just run an HA cluster in a single region if you're looking to keep it simple, just the same way you can run a single-region app on Fly if you like.
We try to go out of our way to say that this stuff isn't a perfect fit for every application or a "best" way to do things. I think if a deployment like this is attractive for your application, you probably know it. I'm certainly not going to evangelize against people scaling up single-region databases!