Easy simple ways that I can think of:

  - look up CherryPy - It's pretty simple to get started and
    a good way to learn something about both web servers and
    websites.

  - you could also check out learn python the hard way 
    (2nd edition) toward the end it has some exercises on
    setting up a website using a framework based on web.py

    http://learnpythonthehardway.org/book/ex50.html

  - of course, Django is the most popular framework and so
    will also have the most documentation.