WxWidgets uses a different approach to Qt. Qt emulates, where as Wx delegates :) i.e. Qt tries to emulate the native look-and-feel, where as Wx uses the native APIs of the platform for rendering GUI. So if you want true native the go with WxWidgets. This is one reason why Qt is available on mobile but Wx has struggled.
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Honestly, the best applications tend to be native applications. That’s my experience at least.
WxWidgets uses a different approach to Qt. Qt emulates, where as Wx delegates :) i.e. Qt tries to emulate the native look-and-feel, where as Wx uses the native APIs of the platform for rendering GUI. So if you want true native the go with WxWidgets. This is one reason why Qt is available on mobile but Wx has struggled.