I think you are making a well reasoned point, but you might be overly kind to mouse models. The common ancestor of mice and humans lived before the dinosaurs went extinct, and humans (as well as other primates) have subsequently had very dramatic changes in genetics for nerve cells. We also live about 100 times longer, and Alzheimer's only ever shows symptoms around 30 years old at the absolute earliest, while a mouse used in experiments is rarely more than 6 months old. Widespread use of grant money to experiment on mice with the justification of researching Alzheimer's, without evidence there is reason to believe the experiment is isolating something meaningful to human expression of the disease, is literally fraud.
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I think you are making a well reasoned point, but you might be overly kind to mouse models. The common ancestor of mice and humans lived before the dinosaurs went extinct, and humans (as well as other primates) have subsequently had very dramatic changes in genetics for nerve cells. We also live about 100 times longer, and Alzheimer's only ever shows symptoms around 30 years old at the absolute earliest, while a mouse used in experiments is rarely more than 6 months old. Widespread use of grant money to experiment on mice with the justification of researching Alzheimer's, without evidence there is reason to believe the experiment is isolating something meaningful to human expression of the disease, is literally fraud.