That 49% has two confounding factors, 1: it includes a significant portion of hiv positive individuals, the efficacy was 60% if you exclude them. 2: N is not large enough to give you reasonable confidence in either of those numbers the ci was between 19%-80%, which is almost useless, not quite, since it seems like there is evidence that it is at least a little less effective, but by how much is still anyone’s guess at this point.