Healthy weight is also a lot more complicated than just one hormone. Taubes is not discussing, for example, the difference between healthy and unhealthy obesity and the role that dysfunctional adipogenesis plays in the latter by inducing hypertrophic changes in fat cells (distended fat cells) rather than hyperplasia (create more fat cells).
A lot of research has focused on finding agonists for PPARgamma to restore healthy adipogenesis and reduce unhealthy inflammation of fat tissue. Some have been taken off the market for suspected toxicities, but piaglitazone is still widely prescribed.
Just wanted to let you know, although it's been a few days, that I genuinely appreciate this reply. I am curious why this got downvoted. It adds context to one of my uncertainties (the exact mechanism for increased satiety under keto) and adds more context as to why obesity is unhealthy in the first place and how the original article is extremely reductive. I don't know of any way to enable notifications for replies to my comments (be it via email or on HN itself) so if anyone knows please let me know!
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It's the increase in leptin that drives satiety under keto diet:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244537/#:~:tex....
Healthy weight is also a lot more complicated than just one hormone. Taubes is not discussing, for example, the difference between healthy and unhealthy obesity and the role that dysfunctional adipogenesis plays in the latter by inducing hypertrophic changes in fat cells (distended fat cells) rather than hyperplasia (create more fat cells).
A lot of research has focused on finding agonists for PPARgamma to restore healthy adipogenesis and reduce unhealthy inflammation of fat tissue. Some have been taken off the market for suspected toxicities, but piaglitazone is still widely prescribed.
Just wanted to let you know, although it's been a few days, that I genuinely appreciate this reply. I am curious why this got downvoted. It adds context to one of my uncertainties (the exact mechanism for increased satiety under keto) and adds more context as to why obesity is unhealthy in the first place and how the original article is extremely reductive. I don't know of any way to enable notifications for replies to my comments (be it via email or on HN itself) so if anyone knows please let me know!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539070/
Why the downvotes?
I didn’t downvote but perhaps the overtly scientific writing. I had trouble understanding it even though I have some background in medicine.