I think most of us here mean Titanium Mobile when we say just "Titanium." Their desktop platform seems to have received much less attention from them, and is of much more questionable benefit than the mobile one, which doesn't have many alternatives whereas on the desktop there's Qt and all sorts of other things available.
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Here's two "show stoppers" that made me stop experimenting with Titanium.
1) If you have a custom UI, dragging the window around is painfully slow and erratic. Resizing the window is actually so slow it's unusable.
2) The built-in zip function doesn't seem to work with files over ~200 MB on Mac OS X.
I tried reaching Titanium, failed, and moved on.
I think most of us here mean Titanium Mobile when we say just "Titanium." Their desktop platform seems to have received much less attention from them, and is of much more questionable benefit than the mobile one, which doesn't have many alternatives whereas on the desktop there's Qt and all sorts of other things available.