Figure3 shows plasma levels following a 36g dose of liposomal vitamin C, for both subjects. This resulted in peak plasma levels, in the region of 400mML21. A 95% interfractile range (34–114), which contains 95% of the distribution with a mean of 74 corresponds to a calculated standard deviation of 17.4. We note that, under these conditions, an outlier measurement of 400mML21 would correspond to a deviation of 10.3 s with a theoretical p-value of 1.6610213 (i.e. p,0.0000000000001). With this high dose, both subjects exceeded their bowel tolerance, leading to diarrhoea. This intolerance presumably arose from the high intake of phospholipid, without food buffering, in fasting individuals. However, our observations using hourly doses suggest that daily intakes of this magnitude are tolerable without bowel effects, as long as the dose is spread throughout the day. https://www.tandfonline.com/doi/abs/10.1080/1359084080230542...