For vitamin C experiments, mice undergoing standard feeding or at the last day of the first FMD cycle started to be treated with vitamin C (4 g/kg in saline) via intraperitoneal injection twice a day, every day until the end of the experiment. At least 6–8 h have elapsed between the two administrations in each day.
EDIT: 4 g/kg twice a day is about 400 grams (0.88 pounds) of Vitamin C per day for a 50 kg (110 pound) person. 1 gram per day is a good rule of thumb for the upper limit of oral supplementation.
Thank you for posting the link to Nature. From the paper, the FMD decreases the ferritin available to tumor cells which makes them more vulnerable to the hydrogen peroxide produced by the metabolism of vitamin C. Do I have that right?
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From the Methods section of the paper [1].
EDIT: 4 g/kg twice a day is about 400 grams (0.88 pounds) of Vitamin C per day for a 50 kg (110 pound) person. 1 gram per day is a good rule of thumb for the upper limit of oral supplementation.
[1] https://www.nature.com/articles/s41467-020-16243-3.pdf#page=...
Thank you for posting the link to Nature. From the paper, the FMD decreases the ferritin available to tumor cells which makes them more vulnerable to the hydrogen peroxide produced by the metabolism of vitamin C. Do I have that right?