Friend of mine, statistics phd, interviewing with big-name University for Prof position. In car on way to airport with junior faculty member, asked "What do you think my chances are?"

Junior said "Nil. You are female with kids. Elderly faculty think you will put them before the job, and not pull your weight. They reject all the mothers."

They did indeed reject her, with a polite letter. Now she works at another big University, very successful, students love her, lucky to have her.

So its not always (almost never) about the resume or interview.