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calling back and forth between C and Python

Yes - the trick really is to move your accelerated code away from python's object model, because then you can drop a lot of overhead and also release the GIL. Tricky, though. Out of interest, did you see any improvement from pypy or numba?

prohibitively unmaintainable

I don't think well written cython should be any more unmaintainable than Go IMHO.

We didn't try numba and couldn't get pypy working; we had dependencies that didn't work with Pypy. I'm curious about numba though.

I don't think well written cython should be any more unmaintainable than Go IMHO.

I've written a lot of Go, it's always struck me as about as maintainable as Python (I would put it at a bit more maintainable than Python given its mature static typing story--mypy still has lots of problems). I haven't given Cython a fair shake, but it doesn't seem very well-invested in; this is generally what has kept me away from it.

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