Speaking as somebody with a Masters in digital anthropology and almost 5 years non-technical experience with startups, who is also a comp sci student now to round out my qualifications, gender does sometimes matter when it really shouldn't.

That said, I don't think focusing on it as a definitive characteristic is helpful at all. I bought codegoddess.com thinking I could make some awesome online hub for female coders, and then realized a chromosomal marker isn't a very good distinguishing feature.