Just because it's a laptop doesn't mean you have to use it in an non-ergonomic configuration. My current setup is a 15"MBP mounted on a sit/stand desk at home. An external keyboard and monitor keeps both hands and eyes in the right position. I have a similar docking setup at the office. That covers 80% of my time on the machine. The other 20% (mostly at coffee shops) doesn't bother me, and I still get the benefits of mobility and freedom.
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Just because it's a laptop doesn't mean you have to use it in an non-ergonomic configuration. My current setup is a 15"MBP mounted on a sit/stand desk at home. An external keyboard and monitor keeps both hands and eyes in the right position. I have a similar docking setup at the office. That covers 80% of my time on the machine. The other 20% (mostly at coffee shops) doesn't bother me, and I still get the benefits of mobility and freedom.