It's good to be able to switch positions. You can get an (expensive) desk that easily adjusts height, or a drafting stool so you can sit at your standing desk, or two desks. I found that I did tire of standing, but getting one of those comfort mats for standing helped, and adding the treadmill so I can walk or stand helped more (and has made it much easier for me to lose weight, I believe).
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It's good to be able to switch positions. You can get an (expensive) desk that easily adjusts height, or a drafting stool so you can sit at your standing desk, or two desks. I found that I did tire of standing, but getting one of those comfort mats for standing helped, and adding the treadmill so I can walk or stand helped more (and has made it much easier for me to lose weight, I believe).