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Paul, could you enlighten us how well does this type of development (Lisp macro/closure based) integrate with JS and Ajax? I'm interested in asynchronicity of the Ajax... Ruby and Python with Protoype and Scriptaculous make this very easy indeed...

How much Ajax do you see on this site? (The answer is that I don't know, because I haven't tried.)

In my experience with Seaside (which uses roughly the same technique), extremely well. There's a demo site at http://scriptaculous.seasidehosting.st/, fwiw.

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