For .NET Core there are binary packages [1] for Debian/Ubuntu, Fedora, Red Hat and SUSE, so you can apt-get/rpm/yum hosting environment in a matter of minutes. I'd say it's easier to set up and run ASP.NET Core app with Apache or nginx as reverse proxy than with IIS. For "old" .NET you are stuck with Mono [2] which works okay-ish if you don't use Windows-only dependencies.
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For .NET Core there are binary packages [1] for Debian/Ubuntu, Fedora, Red Hat and SUSE, so you can apt-get/rpm/yum hosting environment in a matter of minutes. I'd say it's easier to set up and run ASP.NET Core app with Apache or nginx as reverse proxy than with IIS. For "old" .NET you are stuck with Mono [2] which works okay-ish if you don't use Windows-only dependencies.
[1] https://www.microsoft.com/net/download/linux-package-manager...
[2] https://www.mono-project.com/