In vertebrate females, all oogonia mature to oocytes before birth. In males, spermatogonia mature to spermatocytes continuously after puberty. I gather that oocytes and spermatocytes are more sensitive than spermatogonia to radiation damage. Damaged spermatocytes and sperm get replaced after a few weeks. But there's no replacement for damaged oocytes.
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Birth defects
In vertebrate females, all oogonia mature to oocytes before birth. In males, spermatogonia mature to spermatocytes continuously after puberty. I gather that oocytes and spermatocytes are more sensitive than spermatogonia to radiation damage. Damaged spermatocytes and sperm get replaced after a few weeks. But there's no replacement for damaged oocytes.
So yes, birth defects.
That was the old thinking, but now there's evidence that women can probably generate 'new' eggs:
https://www.theguardian.com/science/2016/oct/07/evidence-sug...
https://www.sciencedaily.com/releases/2012/07/120726180259.h...
Wow, that's amazing. But on the other hand, using a chemotherapy drug to ovulate seems a little iffy.