Comment on End-to-end differentiable learning of protein structureparentComments−xiao_haozi8yYes! And I'd also add that there are others that come into play...* Elucidating function by identifying similarity to other known structures* Finding novel signaling mechanisms (see work on PHinder)* Modeling co-receptor/ligand dynamics* Identifying function of orphan receptors* Working with ancestral genes by identifying descendant structure* Classifying and clustering proteins based on solved structure* Learning new biochemical mechanisms through active vs inactive state structures...
Comments
Yes! And I'd also add that there are others that come into play...
* Elucidating function by identifying similarity to other known structures
* Finding novel signaling mechanisms (see work on PHinder)
* Modeling co-receptor/ligand dynamics
* Identifying function of orphan receptors
* Working with ancestral genes by identifying descendant structure
* Classifying and clustering proteins based on solved structure
* Learning new biochemical mechanisms through active vs inactive state structures
...